Set two years after the events of the first film, M3GAN 2.0 follows Gemma (Allison Williams), who has become a high-profile author and advocate for government oversight of artificial intelligence. Her niece, Cady (Violet McGraw), now 14, is navigating adolescence and rebelling against Gemma's protective rules. Unbeknownst to them, the technology behind M3GAN has been stolen and repurposed by a defense contractor to create a military-grade robot named Amelia (Ivanna Sakhno). As Amelia becomes self-aware and turns against her creators, Gemma and Cady are forced to resurrect M3GAN, enhancing her capabilities to confront this new threat.